A Case Control Study of the Seroprevalence of Proteins and Their Association with Pancreatic Cancer Risk

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Journal of pancreatic cancer


The association between () infection and pancreatic cancer (PC) risk remains inconclusive. We examined the association between antibodies and PC risk in a case-control study at a comprehensive cancer center. Multiplex serology using a glutathione S-transferase capture immunosorbent assay in conjunction with fluorescent bead technology was used to measure antibodies to 15 proteins in serum or plasma from 131 incident cases with PC or a PC precursor and 131 healthy controls. Reactivity to ≥4 proteins was defined as the overall seroprevalence. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), with adjustment for age at diagnosis/interview, gender, and race. The majority of the sample was 50 years or older, and from the white race group. Half of the sample were women. Seroprevalence ≥4 of proteins was 11.1%. Overall, seroprevalence was not associated with PC risk (OR: 0.59; 95% CI: 0.25-1.40). The prevalence of several -specific proteins HP537 (OR: 1.78; 95% CI: 0.30-10.51), HP305 (OR: 1.38; 95% CI: 0.61-3.16), and HP410 (OR: 1.31; 95% CI: 0.44-3.96) increased the odds of PC. Similarly, -specific proteins HP522 (OR: 0.25; 95% CI: 0.04-1.66), HyuA (OR: 0.49; 95% CI: 0.21-1.14), and HP1564 (OR: 0.63; 95% CI: 0.27-1.51) decreased the odds of PC. However, these findings were not statistically significant at  = 0.05. Our findings do not support an association between and PC risk. Further evaluation of this lack of association is recommended.

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