Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019


Dongze Wu, University of Electronic Science and Technology of China
Yingzhao Jin, Chinese University of Hong Kong
Yuhan Xing, Chinese University of Hong Kong
Melsew Dagne Abate, Woldia University
Mohammadreza Abbasian, Harvard Medical School
Mohsen Abbasi-Kangevari, Non-Communicable Diseases Research Center
Zeinab Abbasi-Kangevari, Shahid Beheshti University of Medical Sciences
Foad Abd-Allah, Faculty of Medicine
Michael Abdelmasseh, Joan C. Edwards School of Medicine
Mohammad Amin Abdollahifar, University of Saskatchewan
Deldar Morad Abdulah, University of Duhok
Aidin Abedi, University of Southern California
Vida Abedi, Pennsylvania State University
Hassan Abidi, Yasuj University of Medical Sciences
Richard Gyan Aboagye, University of Health and Allied Sciences, Ghana
Hassan Abolhassani, Research Center for Immunodeficiencies
Katrina Abuabara, University of California, San Francisco
Morteza Abyadeh, Virginia Commonwealth University
Isaac Yeboah Addo, UNSW Sydney
Kayode Nelson Adeniji, East Carolina University
Abiola Victor Adepoju, Jhpiego Corporation
Miracle Ayomikun Adesina, University of Ibadan
Qorinah Estiningtyas Sakilah Adnani, Universitas Padjadjaran
Mohsen Afarideh, Endocrinology and Metabolism Research Center
Shahin Aghamiri, Shahid Beheshti University of Medical Sciences
Antonella Agodi, Università degli Studi di Catania, Scuola di Medicina
Anurag Agrawal, Ashoka University
Constanza Elizabeth Aguilera Arriagada, Complejo Asistencial Dr. Sótero del Río
Aqeel Ahmad, Shahid Beheshti University of Medical Sciences
Danish Ahmad, University of Canberra
Sajjad Ahmad, Abasyn University
Sohail Ahmad, Abasyn University
Ali Ahmadi, Shahid Beheshti University of Medical Sciences

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Background: The causes for immune-mediated inflammatory diseases (IMIDs) are diverse and the incidence trends of IMIDs from specific causes are rarely studied. The study aims to investigate the pattern and trend of IMIDs from 1990 to 2019. Methods: We collected detailed information on six major causes of IMIDs, including asthma, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, psoriasis, and atopic dermatitis, between 1990 and 2019, derived from the Global Burden of Disease study in 2019. The average annual percent change (AAPC) in number of incidents and age standardized incidence rate (ASR) on IMIDs, by sex, age, region, and causes, were calculated to quantify the temporal trends. Findings: In 2019, rheumatoid arthritis, atopic dermatitis, asthma, multiple sclerosis, psoriasis, inflammatory bowel disease accounted 1.59%, 36.17%, 54.71%, 0.09%, 6.84%, 0.60% of overall new IMIDs cases, respectively. The ASR of IMIDs showed substantial regional and global variation with the highest in High SDI region, High-income North America, and United States of America. Throughout human lifespan, the age distribution of incident cases from six IMIDs was quite different. Globally, incident cases of IMIDs increased with an AAPC of 0.68 and the ASR decreased with an AAPC of −0.34 from 1990 to 2019. The incident cases increased across six IMIDs, the ASR of rheumatoid arthritis increased (0.21, 95% CI 0.18, 0.25), while the ASR of asthma (AAPC = −0.41), inflammatory bowel disease (AAPC = −0.72), multiple sclerosis (AAPC = −0.26), psoriasis (AAPC = −0.77), and atopic dermatitis (AAPC = −0.15) decreased. The ASR of overall and six individual IMID increased with SDI at regional and global level. Countries with higher ASR in 1990 experienced a more rapid decrease in ASR. Interpretation: The incidence patterns of IMIDs varied considerably across the world. Innovative prevention and integrative management strategy are urgently needed to mitigate the increasing ASR of rheumatoid arthritis and upsurging new cases of other five IMIDs, respectively. Funding: The Global Burden of Disease Study is funded by the Bill and Melinda Gates Foundation. The project funded by Scientific Research Fund of Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital ( 2022QN38).



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