HPV-11 variability, persistence and progression to genital warts in men: The HIM study
Document Type
Article
Publication Title
Journal of General Virology
Abstract
HPV-11 and HPV-6 are the etiological agents of about 90% of genital warts (GWs). The intra-typic variability of HPV-11 and its association with infection persistence and GW development remains undetermined. Here, HPV infection in men (HIM) participants who had an HPV-11 genital swab and/or GW, preceded or not by a normal skin genital swab were analysed. Genomic variants were characterized by PCR-sequencing and classified within lineages (A, B) and sublineages (A1, A2, A3, A4). HPV-11 A2 variants were the most frequently detected in the genital swab samples from controls and in both genital swabs and GW samples from cases. The same HPV-11 variant was detected in the GW sample and its preceding genital swab. There was a lack of association between any particular HPV-11 variant and the increased risk for GW development.
First Page
2339
Last Page
2342
DOI
10.1099/jgv.0.000896
Publication Date
9-1-2017
Recommended Citation
Flores-Díaz, Ema; Sereday, Karen A.; Ferreira, Silvaneide; Sirak, Bradley; Sobrinho, João Simão; Baggio, Maria Luiza; Galan, Lenice; Silva, Roberto C.; Lazcano-Ponce, Eduardo; Giuliano, Anna R.; Villa, Luisa L.; Sichero, Laura; Lin, Huiyi; Messina, Jane; Campbell, Christine Pierce; Gage, Christine; Ingles, Donna J.; Isaacs, Kim; Kennedy, Kayoko; Bobanic, Andrea; Rahman, Shams; Schabath, Matthew; Nyitray, Alan; Rathwell, Julie; Cintra, Ricardo; Cernicchiaro, Filomena; Ribeiro, Graça; Otero, Rosária; Bocalon, Roberta; Antunes, Juliana; Silva, Fernanda; Terreri, Rossana; and Valdez, Aurelio Cruz, "HPV-11 variability, persistence and progression to genital warts in men: The HIM study" (2017). Global Population Health Faculty Publications. 41.
https://doi.org/10.1099/jgv.0.000896
https://collections.uhsp.edu/global-population-health_pubs/41