Efforts towards the inhibitor design for New Delhi metallo-beta-lactamase (NDM-1)
Document Type
Article
Publication Title
European Journal of Medicinal Chemistry
Abstract
Antimicrobial stewardship is imperative when treating bacterial infections because the misuse and overuse of antibiotics have caused pathogens to develop life-threatening resistance mechanisms. The New Delhi metallo-beta-lactamase (NDM-1) is one of many enzymes that enable bacterial resistance. NDM-1 is a more recently discovered beta-lactamase with the ability to inactivate a wide range of beta-lactam antibiotics. Multiple NDM-1 inhibitors have been designed and tested; however, due to the complexity of the NDM-1 active site, there is currently no inhibitor on the market. Consequently, an infection caused by bacteria possessing the gene for the NDM-1 enzyme is a serious and potentially fatal complication. An abundance of research has been invested over the past decade in search of an NDM-1 inhibitor. This review aims to summarize various NDM-1 inhibitor designs that have been developed in recent years.
DOI
10.1016/j.ejmech.2021.113747
Publication Date
12-5-2021
Recommended Citation
Nagulapalli Venkata, Kalyan C.; Ellebrecht, Morgan; and Tripathi, Siddharth K., "Efforts towards the inhibitor design for New Delhi metallo-beta-lactamase (NDM-1)" (2021). Pharmaceutical and Administrative Sciences Faculty Publications. 113.
https://doi.org/10.1016/j.ejmech.2021.113747
https://collections.uhsp.edu/pharm-admin-sciences_pubs/113