Correcting the effect of hematocrit in whole blood coagulation analysis on paper-based lateral flow device

Authors

Hua Li, College of Engineering and Applied Science
Daewoo Han, College of Engineering and Applied Science
Giovanni M. Pauletti, University of Cincinnati
Michael A. Hegener, University of Cincinnati
Andrew J. Steckl, College of Engineering and Applied Science

Document Type

Article

Publication Title

Analytical Methods

Abstract

A simple method to correct the effect of hematocrit (Hct) on a paper-based lateral flow assay device that is designed to assess whole blood coagulation is reported. By quantifying the effect of Hct on red blood cell (RBC) transport, a calibration procedure is obtained that compensates for the Hct effect, while maintaining the dependence of blood coagulation on RBC transport.

First Page

2869

Last Page

2874

DOI

10.1039/c8ay00192h

Publication Date

6-28-2018

Recommended Citation

Li, Hua; Han, Daewoo; Pauletti, Giovanni M.; Hegener, Michael A.; and Steckl, Andrew J., "Correcting the effect of hematocrit in whole blood coagulation analysis on paper-based lateral flow device" (2018). Pharmaceutical and Administrative Sciences Faculty Publications. 142. https://doi.org/10.1039/c8ay00192h
https://collections.uhsp.edu/pharm-admin-sciences_pubs/142