Cellulose-based lateral flow device for low-cost point-of-care blood coagulation monitoring
Document Type
Conference Proceeding
Publication Title
International Conference on Nanotechnology for Renewable Materials 2018
Abstract
1. Introduction to no-reaction lateral flow assay (nrLFA) device • Consists of sample pad, analytical membrane and wicking pad; paper-based and low-cost 2. Properties of various analytical membranes, SEM images of nitrocellulose membranes 3. Reproducibility of nrLFA device using various body fluids (whole blood, plasma, artificial sweat, etc.) • t ≥ 60 s, CV < 7% for ail fluids; t ≥ 80 s, CV ∼1.5% for RBC component in whole blood 4. Effect of hematocrit (Hct) and sample volume on fluid transport in nrLFA device • Larger Hct results in shorter RBC distance in nrLFA (monotonie); minimum sample volume: 20 μL 5. nrLFA device for blood coagulation monitoring • Stronger coagulation results in shorter RBC distance in nrLFA (monotonie); better detection range and linearity than fibrintimer 6. Clinical trial of nrLFA device with patients on anticoagulation therapy • nrLFA capable to statistically distinguish blood coagulation between patients with different INR 7. Blood coagulation nrLFA in veterinary applications.
First Page
255
Last Page
264
Publication Date
1-1-2018
Recommended Citation
Li, Hua; Han, Daewoo; Pauletti, Giovanni; Hegener, Michael; and Steckl, Andrew, "Cellulose-based lateral flow device for low-cost point-of-care blood coagulation monitoring" (2018). Pharmaceutical and Administrative Sciences Faculty Publications. 145.
https://collections.uhsp.edu/pharm-admin-sciences_pubs/145