Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery

Authors

Hui Yun Wen, Tongji University
Hai Qing Dong, Tongji University
Wen Juan Xie, Tongji University
Yong Yong Li, Tongji University
Kang Wang, Tongji University
Giovanni M. Pauletti, University of Cincinnati
Dong Lu Shi, Tongji University

Document Type

Article

Publication Title

Chemical Communications

Abstract

The synthesis and biological efficacy of novel nanomicelles that rapidly disassemble and release their encapsulated payload intracellularly under tumor-relevant glutathione (GSH) levels are reported. The unique design includes a PEG-sheddable shell and poly(ε-benzyloxycarbonyl-l-lysine) core with a redox-sensitive disulfide linkage. © 2011 Royal Society of Chemistry.

First Page

3550

Last Page

3552

DOI

10.1039/c0cc04983b

Publication Date

3-8-2011

Recommended Citation

Wen, Hui Yun; Dong, Hai Qing; Xie, Wen Juan; Li, Yong Yong; Wang, Kang; Pauletti, Giovanni M.; and Shi, Dong Lu, "Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery" (2011). Pharmaceutical and Administrative Sciences Faculty Publications. 166. https://doi.org/10.1039/c0cc04983b
https://collections.uhsp.edu/pharm-admin-sciences_pubs/166