Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies
Document Type
Article
Publication Title
Advanced Drug Delivery Reviews
Abstract
Clinical development of orally active peptide drugs has been restricted by their unfavorable physicochemical properties, which limit their intestinal mucosal permeation and their lack of stability against enzymatic degradation. Successful oral delivery of peptides will depend, therefore, on strategies designed to alter the physicochemical characteristics of these potential drugs, without changing their biological activity, in order to overcome the physical and biochemical barrier properties of the intestinal cells. This manuscript will focus on the physiological limitations for oral peptide delivery and on various strategies using chemical modifications to improve oral bioavailability of peptide-based drugs.
First Page
235
Last Page
256
DOI
10.1016/S0169-409X(97)00045-8
Publication Date
9-15-1997
Recommended Citation
Pauletti, Giovanni M.; Gangwar, Sanjeev; Siahaan, Teruna J.; Aubé, Jeffrey; and Borchardt, Ronald T., "Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies" (1997). Pharmaceutical and Administrative Sciences Faculty Publications. 199.
https://doi.org/10.1016/S0169-409X(97)00045-8
https://collections.uhsp.edu/pharm-admin-sciences_pubs/199