Prodrug strategies to enhance the intestinal absorption of peptides
Document Type
Article
Publication Title
Drug Discovery Today
Abstract
Clinical development of orally active peptide drugs has been restricted by the unfavorable physicochemical properties of these molecules limiting intestinal mucosal permeation and the lack of stability of peptides against enzymatic degradation. Successful oral delivery of peptides will depend, therefore, on strategies designed to alter the physicochemical characteristics of these potential drugs, without changing their biological activity, in order to increase the permeation across intestinal cells. This manuscript will focus on the biological barrier properties that limit oral peptide bioavailability and on prodrug strategies designed to overcome these barriers.
First Page
148
Last Page
155
DOI
10.1016/S1359-6446(97)01011-8
Publication Date
4-1-1997
Recommended Citation
Gangwar, Sanjeev; Pauletti, Giovanni M.; Wang, Binghe; Siahaan, Teruna J.; Stella, Valentino J.; and Borchardt, Ronald T., "Prodrug strategies to enhance the intestinal absorption of peptides" (1997). Pharmaceutical and Administrative Sciences Faculty Publications. 202.
https://doi.org/10.1016/S1359-6446(97)01011-8
https://collections.uhsp.edu/pharm-admin-sciences_pubs/202