Enterococcus faecalis resistant to linezolid: Case series and review of the literature
Document Type
Article
Publication Title
Pharmacotherapy
Abstract
Reports of linezolid resistance among Enterococcus faecalis have been relatively rare. We describe three patients with linezolid-resistant strains of E. faecalis, discovered after the patients had received long courses (> 30 days) of linezolid therapy. All strains contained the G2576U mutation in 23S rRNA. A literature review revealed one other case in the United States and three cases in Europe; all involved patients who had received long courses of therapy. It appears that recent or extended linezolid therapy may be a risk factor for development of resistant E. faecalis. In patients who have recently been treated with linezolid and have an identified new systemic enterococcal isolate, linezolid sensitivity should be verified as soon as possible to guide therapy. This strategy also should be considered for patients with a breakthrough enterococcal isolate during linezolid therapy.
First Page
1225
Last Page
1231
DOI
10.1592/phco.24.13.1225.38086
Publication Date
9-4-2004
Recommended Citation
Burleson, Brian S.; Ritchie, David J.; Micek, Scott T.; and Dunne, W. Michael, "Enterococcus faecalis resistant to linezolid: Case series and review of the literature" (2004). Pharmacy Practice Faculty Publications. 181.
https://doi.org/10.1592/phco.24.13.1225.38086
https://collections.uhsp.edu/pharm-practice_pubs/181