Systematic review and meta-analysis of community pharmacy error rates in the USA: 1993-2015
Document Type
Article
Publication Title
BMJ Open Quality
Abstract
Importance: While much is known about hospital pharmacy error rates in the USA, comparatively little is known about community pharmacy dispensing error rates. Objective: The aim of this study was to determine the rate of community pharmacy dispensing errors in the USA. Methods: English language, peer-reviewed observational and interventional studies that reported community pharmacy dispensing error rates in the USA from January 1993 to December 2015 were identified in 10 bibliographic databases and topic-relevant grey literature. Studies with a denominator reflecting the total number of prescriptions in the sample were necessary for inclusion in the meta-analysis. A random effects meta-analysis was conducted to estimate an aggregate community pharmacy dispensing error rate. Heterogeneity was assessed using the I2 statistic prior to analysis. Results: The search yielded a total of 8490 records, of which 11 articles were included in the systematic review. Two articles did not have adequate data components to be included in the meta-analysis. Dispensing error rates ranged from 0.00003% (43/1 420 091) to 55% (55/100). The meta-analysis included 1 461 128 prescriptions. The overall community pharmacy dispensing error rate was estimated to be 0.015 (95% CI 0.014 to 0.018); however, significant heterogeneity was observed across studies (I2 = 99.6). Stratification by study error identification methodology was found to have a significant impact on dispensing error rate (p<0.001). Conclusion and relevance: There are few published articles that describe community pharmacy dispensing error rates in the USA. Thus, there is limited information about the current rate of community pharmacy dispensing errors. A robust investigation is needed to assess dispensing error rates in the USA to assess the nature and magnitude of the problem and establish prevention strategies.
DOI
10.1136/bmjoq-2017-000193
Publication Date
10-1-2018
Recommended Citation
Campbell, Patrick J.; Patel, Mira; Martin, Jennifer R.; Hincapie, Ana L.; Axon, David Rhys; Warholak, Terri L.; and Slack, Marion, "Systematic review and meta-analysis of community pharmacy error rates in the USA: 1993-2015" (2018). Pharmacy Practice Faculty Publications. 405.
https://doi.org/10.1136/bmjoq-2017-000193
https://collections.uhsp.edu/pharm-practice_pubs/405