Importance of site of infection and antibiotic selection in the treatment of carbapenem-resistant Pseudomonas aeruginosa Sepsis
Document Type
Article
Publication Title
Antimicrobial Agents and Chemotherapy
Abstract
In a retrospective analysis of 215 patients with carbapenem-resistant Pseudomonas aeruginosa sepsis, we observed a significantly higher risk of mortality associated with respiratory tract infection (risk ratio [RR], 1.20; 95% confidence interval [CI], 1.04 to 1.39; P = 0.010) and lower risk with urinary tract infection (RR, 0.80; 95% CI, 0.71 to 0.90; P = 0.004). Aminoglycoside monotherapy was associated with increased mortality, even after adjusting for confounders (adjusted RR, 1.72; 95% CI, 1.03 to 2.85; P = 0.037), consistent across multiple sites of infection.
DOI
10.1128/AAC.02400-17
Publication Date
4-1-2018
Recommended Citation
Britt, Nicholas S.; Ritchie, David J.; Kollef, Marin H.; Burnham, Carey Ann D.; Durkin, Michael J.; Hampton, Nicholas B.; and Micek, Scott T., "Importance of site of infection and antibiotic selection in the treatment of carbapenem-resistant Pseudomonas aeruginosa Sepsis" (2018). Pharmacy Practice Faculty Publications. 44.
https://doi.org/10.1128/AAC.02400-17
https://collections.uhsp.edu/pharm-practice_pubs/44