Internal switches modulating electron tunneling currents in respiratory complex III
Document Type
Article
Publication Title
Biochimica et Biophysica Acta - Bioenergetics
Abstract
In different X-ray crystal structures of bc1 complex, some of the key residues of electron tunneling pathways are observed in different conformations; here we examine their relative importance in modulating electron transfer and propose their possible gating function in the Q-cycle. The study includes inter-monomeric electron transfer; here we provide atomistic details of the reaction, and discuss the possible roles of inter-monomeric electronic communication in bc1 complex. Binding of natural ligands or inhibitors leads to local conformational changes which propagate through protein and control the conformation of key residues involved in the electron tunneling pathways. Aromatic-aromatic interactions are highly utilized in the communication network since the key residues are aromatic in nature. The calculations show that there is a substantial change of the electron transfer rates between different redox pairs depending on the different conformations acquired by the key residues of the complex.
First Page
749
Last Page
758
DOI
10.1016/j.bbabio.2016.02.005
Publication Date
6-1-2016
Recommended Citation
Hagras, Muhammad A. and Stuchebrukhov, Alexei A., "Internal switches modulating electron tunneling currents in respiratory complex III" (2016). Basic Sciences Faculty Publications. 110.
https://doi.org/10.1016/j.bbabio.2016.02.005
https://collections.uhsp.edu/basic-sciences_pubs/110