Quiet breathing in hindlimb casted mice

Authors

Candace N. Receno, Le Moyne College
Katelynn E. Roffo, Le Moyne College
Marisa C. Mickey, Syracuse University
Keith C. DeRuisseau, Syracuse University
Lara R. DeRuisseau, Le Moyne College

Document Type

Article

Publication Title

Respiratory Physiology and Neurobiology

Abstract

The hindlimb casting model was developed to study skeletal muscle reloading following a period of unloading. It is unknown if ventilation parameters of mice are affected by the casting model. We tested the hypothesis that hindlimb casted mice have similar ventilatory patterns compared to mice with the casts removed. Male CD-1 mice underwent 14 days of hindlimb immobilization via plaster casting. Breathing parameters were obtained utilizing unrestrained barometric plethysmography (UBP). Breathing traces were analyzed with Ponemah software for breathing frequency, tidal volume (TV), and minute ventilation (MV). Frequency, TV and MV did not show any differences in quiet breathing patterns during or post-casting in mice. Thus, the hindlimb casting model does not complicate breathing during and after casting and should not interfere with the unloading and reloading of skeletal muscle.

First Page

82

Last Page

85

DOI

10.1016/j.resp.2018.06.003

Publication Date

12-1-2018

Recommended Citation

Receno, Candace N.; Roffo, Katelynn E.; Mickey, Marisa C.; DeRuisseau, Keith C.; and DeRuisseau, Lara R., "Quiet breathing in hindlimb casted mice" (2018). Basic Sciences Faculty Publications. 35. https://doi.org/10.1016/j.resp.2018.06.003
https://collections.uhsp.edu/basic-sciences_pubs/35